徐梦佳博士,中国科学院宁波材料技术与工程研究所副研究员。2020年毕业于中国科学院大学,获得工学博士学位后,2021-2023年在南京农业大学进行博士后研究,出站后留宁波材料所担任客聘助理研究员,同年晋升副研究员。主要从事植物/海洋生物活性物质功效评价及肠道菌群互作改善慢性肝病机制探究;微生物快速检测、鉴定及活性评估技术开发。近年来以第一作者/通讯作者于Sens. Actuators B Chem., Talanta., Foods, Front. Med等期刊发表论文6篇,共发表SCI收录论文17篇,申请发明专利7项,获授权4项。作为项目负责人主持国家自然科学基金项目、宁波市自然科学基金项目、中央高校基本科研专项项目、医院横向技术服务等项目;作为核心成员参与宁波市自然科学基金项目(重点项目)、慈溪市人民医院医疗健康集团(慈溪市人民医院)重点学科建设(感染科)项目、宁波市生命健康重大项目(已结题)和宁波市公益项目(已结题)等项目,参加10余次国际/国内会议。
2023.08-至 今,中国科学院宁波材料技术与工程研究所,副研究员
2020.11-2023.08,中国科学院宁波材料技术与工程研究所,客聘助理研究员
2020.12-2023.04,南京农业大学,博士后
2017.09-2020.09,中国科学院宁波材料技术与工程研究所,获材料物理与化学博士学位
2016.04-2017.08,中国科学院宁波材料技术与工程研究所,高级助理
2014.09-2015.11,英国伦敦国王学院,获分子生物医学硕士学位
2010.09-2014.06,南京农业大学,获生物工程本科学位
研究方向:
植物/海洋生物活性物质提取及其调控慢性肝病研究;
基于核酸纳米探针的海洋食源性致病菌和过敏原的传感技术开发
发表论文:
(1) Xu M., Wang X., Tian J., Chen, J*., Wei X*., Li W*. A clamp-improved universal amplified system for ratiometric fluorescent detection of single-nucleotide polymorphisms coupled with a novel dual-emissive silver nanocluster. Sensors and Actuator B: Chemistry. 2022, 367: 132151.
(2) Xu M., Li Z., Zhao X., Li W*. Prebiotic properties of exopolysaccharides from Lactobacillus helveticus LZ-R-5 and L. pentosus LZ-R-17 evaluated by in vitro simulated digestion and fermentation. Foods. 2022, 11: 2501.
(3) Xu M., Xing S., Zhao Y., Zhao C*. Peptide nucleic acid-assisted colorimetric d etection of single-nucleotide polymorphisms based on the intrinsic peroxidase-like activity of he min-carbon nanotube nanocomposites. Talanta. 2021, 232: 122420.
(4) Cao J, Xu Z, Xu M*., Ma Y*., Zhao Y. A two-stage framework for optical coherence tomography angiography image quality improvement. Frontiers in medcine, 2022, 10: 1061357.
(5) Xu M., Fu P., Xing S., Zhao Y., Zhao C*. A PNA-DNA2 triple-helix molecular sw itch-based colorimetric sensor for sensitive and specific detection of microRNAs from cancer cells. ChemBioChem. 2020, 21: 2667-2675.
(6) Xu M., Xing S., Xu X., Fu P., Xu W., Zhao C*. Label-free colorimetric aptasensor for highly sensitive and selective detection of proteins by using PNA/DNA hybrids and a cyanine dye.Analytical Methods. 2018, 10: 3824-3829.
(8) Yu X., Ding S., Zhao Y., Xu M., Wu Z., Zhao C. A highly sensitive and robust electrochemical biosensor for microRNA detection based on PNA-DNA hetero-three-way junction formation and target-recycling catalytic hairpin assembly amplification. Talanta. 2023, 266: 125020.
(9) Wang X., Xu M., Xu D., Ma K., Zhang C., Wang G., Dong M., Li W*. Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12. Carbohydrate Polymers, 2022, 296: 119971.
(7) Guo S., Chang H., Xu M., Wang C., Wei H., Li D., Chen J*., Zhou Y*., Liu Y*. Co2+-mediated hydrogels with enhanced mechanical properties for flexible sensing. ACS Applied Polymer Materials. 2022, 4(9): 6403-6413.
(10) Fu P., Xu M., Xing S., Zhao Y., Zhao C*. Dual cascade isothermal amplification reaction based glucometer sensors for point-of-care diagnostics of cancer-related microRNAs. Analyst. 2021, 146: 3242-3250.
(11) Wang X., Li W., Xu M., Tian J., Li W*. The microbial diversity and biofilm-forming characteristic of two traditional Tibetan Kefir grains. Foods. 2021, 11(1): 12.
(12) Fu P., Xing S., Xu M., Zhao Y., Zhao C*. Peptide nucleic acid-based electrochemical biosensor for simultaneous detection of multiple microRNAs from cancer cells with catalytic hairpin assembly amplification. Sensors and Actuator B: Chemistry. 2020, 305: 127545.
(13) Gao T., Xing S., Xu M., Fu P., Yao J., Zhang X., Zhao Y., Zhao C*. A peptide nucleic acid–regulated fluorescence resonance energy transfer DNA assay based on the use of carbon dots and gold nanoparticles. Microchimica Acta. 2020, 187: 375.
(14) Xu X., Xing S., Xu M., Fu P., Gao T., Zhang X., Zhao Y., Zhao C*. Highly sensitive and specific screening of EGFR mutation using a PNA microarray-based fluorometric assay based on rolling circle amplification and graphene oxide. RSC Advances. 2019, 9: 38298-38308.
(15) Xing S., Xu X., Fu P., Xu M., Gao T., Zhang X., Zhao C*. Colorimetric detection of single base-pair mismatches based on the interactions of PNA and PNA/DNA complexes with unmodified gold nanoparticles. Colloids and Surfaces B: Biointerfaces. 2019, 181: 333-340.
(16) Xu W., Xing S., Xu X., Xu M., Fu P., Gao T., Zhao C*. Peptide nucleic acid-assisted label-free detection of single-nucleotide polymorphisms based on light scattering of carbon nanotubes. ACS OMEGA. 2018, 3: 17835-17841.
(17) Yip Y., Pernigo S., Sangera A., Xu, M., Parsons M., Steiner RA*., Dodding MP*. The light chains of kinesin-1 are autoinhibited. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016, 113(9): 2418-2423.
授权专利:
- 徐梦佳; 魏晓捷; 一种比率型银纳米簇荧光探针及其制备方法与应用, 2023-4-7, 中国, ZL 202210153135.6
- 徐梦佳; 赵超; 邢淑; 付盼; 徐小军; 徐皖星; 一种凝血酶检测方法及其试剂盒, 2021-6-8, 中国, ZL 201810552184 .0
- 徐小军; 赵超; 邢淑; 付盼; 徐梦佳; 徐皖星; 基因缺失突变的荧光检测试剂盒和荧光检测方法, 2021-10-8, 中国, ZL 201810682300.0
- 付盼; 赵超; 徐皖星; 邢淑; 徐梦佳; 一种巯基功能化肽核酸增强银纳米簇荧光信号检测单核酸多态性的方法及其应用, 2023-6-6, 中国, 201910608658 .3
申请专利:
(1) 徐梦佳; 赵超; 徐皖星; 邢淑; 一种检测单核苷酸多态性的方法, 2019-6-25, 中国, 201910553022 .3
(2) 付盼; 赵超; 徐梦佳; 邢淑; 张晓康; 一种microRNAs检测试剂盒及检测方法和应用, 2020-7-17, 中国, 202010691475 .5
(3) 邢淑; 赵超; 徐皖星; 徐梦佳; 徐小军; 付盼; 一种单核苷酸多态性的比色检测方法及试剂盒, 2018 -5-31, 中国, 201810552198 .2